Prescription Glimepiride Drug Information

Do NOT use glimepiride if: you are allergic to any ingredient in glimepiride you have certain severe problems associated with diabetes (eg, diabetic coma, diabetic ketoacidosis) you have moderate to severe burns, or very high blood acid levels (acidosis) you are taking bosentan Before using glimepiride: Some medical conditions may interact with glimepiride. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have had a severe allergic reaction (eg, a severe rash, hives, breathing difficulties, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide if you have a history of stroke or liver, kidney, thyroid, heart, or blood vessel problems if you have stomach or bowel problems (eg, stomach or bowel blockage, stomach paralysis), drink alcohol, or have had poor nutrition if you have type 1 diabetes, anemia, very poor health, a high fever, a severe infection, severe diarrhea, high blood acid levels, or brain or nervous system problems, or have had a severe injury if you have low levels of an enzyme called glucose 6-phosphate dehydrogenase (G6PD) if you have a history of certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]) or low blood sodium levels if you will be having surgery Some MEDICINES MAY INTERACT with glimepiride. Tell your health care provider if you are taking any other medicines, especially any of the following: Bosentan because liver problems may occur; the effectiveness of both medicines may be decreased Beta-blockers (eg, propranolol) because the risk of low blood sugar may be increased. They may also hide certain signs of low blood sugar and make it more difficult to notice Anticoagulants (eg, warfarin), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, metformin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), or sulfonamides (eg, sulfamethoxazole) because the risk of low blood sugar may be increased Corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine, terbutaline), or thyroid supplements (eg, levothyroxine) because they may decrease glimepiride's effectiveness, resulting in high blood sugar Gemfibrozil because blood sugar may be increased or decreased